5-Fluorouracil Rechallenge After Cardiotoxicity
نویسندگان
چکیده
منابع مشابه
Successful capecitabine rechallenge following 5-fluorouracil-induced Takotsubo syndrome.
Cardiac toxicity is a widely reported complication of fluoropyrimidine chemotherapies (5-fluorouracil and capecitabine); however, Takotsubo syndrome (TS) is less widely reported. There is little data available describing the viability of fluoropyrimidine rechallenge after fluoropyrimidine-induced TS. We report the case of Ms X, a 41-year-old woman with metastatic oesophageal cancer, who develop...
متن کامل5-fluorouracil induced cardiotoxicity: review of the literature.
5-fluorouracil (5-FU) is a key chemotherapeutic agent in the treatment of many gastrointestinal tract adenocarcinomas. Despite its proven therapeutic efficacy, 5-FU also possesses several undesired cardiac toxicities, including coronary vasospasm, coronary thrombosis, cardiomyopathy, and sudden cardiac death. This review addresses the incidence, mechanisms of action, clinical presentation, risk...
متن کامل5-Fluorouracil-induced cardiotoxicity mimicking myocardial infarction: a case report
BACKGROUND Severe cardiotoxicity is a documented, but very unusual side-effect of intravenous 5-fluorouracil therapy. The mechanism producing cardiotoxicity is poorly understood. CASE PRESENTATION A case of 5-fluorouracil-induced cardiotoxicity, possibly due to coronary artery spasm, and mimicking acute anterolateral myocardial infarction is presented and discussed. Electrocardiographs highli...
متن کاملRight atrial thrombus from inferior vena cava after acute cardiotoxicity of 5-fluorouracil.
We reported a case of large right atrial thrombus which migrated from the inferior vena cava after acute left ventricular dysfunction due to 5-Fluorouracil cardiotoxicity. The patient had recurrent episodes of chest pain and dyspnea suggestive of pulmonary thromboembolism and several days later control echocardiography showed that the right atrial thrombus had disappeared. The patient was disch...
متن کاملBolus 5-fluorouracil as an alternative in patients with cardiotoxicity associated with infusion 5-fluorouracil and capecitabine: a case series.
BACKGROUND 5-Fluorouracil (5-FU) is the backbone of chemotherapy regimens approved for treatment of colorectal cancer. The incidence of cardiotoxicity associated with 5-FU ranges from 1.5% to 18%; 48% as anginal symptoms and 2% as cardiogenic shock. Cardiotoxicity is unpredictable and no alternative chemotherapeutics have been defined so far. PATIENTS AND METHODS We present a case series of s...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: American Journal of Case Reports
سال: 2020
ISSN: 1941-5923
DOI: 10.12659/ajcr.924446